Begin by filling a large pot with salted water and bringing it to a rolling boil over high heat. Once boiling, add the elbow macaroni and cook for 8-10 minutes until al dente; it should be tender yet firm to the bite. Drain the pasta in a colander, then set it aside.

In a medium saucepan, melt 1/4 cup of unsalted butter over medium heat. Swirl the pan occasionally as the butter melts until it begins to foam slightly.

Sprinkle in 1/4 cup of all-purpose flour into the melted butter, whisking continuously for about 1-2 minutes until it turns light golden.

Slowly whisk in 2 cups of whole milk and 1 cup of heavy cream to the roux until smooth. Stir over medium heat until thickened, about 4-5 minutes.

Once thickened, stir in salt, black pepper, garlic powder, and onion powder to taste.

Gradually add the shredded sharp cheddar, mild cheddar, mozzarella, gouda, and parmesan cheeses to the thickened sauce, stirring until melted and incorporated.

Gently fold the cooked macaroni into the cheese sauce until every piece is coated.

Pour the macaroni and cheese mixture into a greased 9x13-inch baking dish, spreading it evenly.

In a small bowl, mix 1 cup of panko breadcrumbs with 2 tablespoons of melted butter until coated. Sprinkle over the mac and cheese.

Place the baking dish in a preheated oven at 350°F (175°C) and bake for 20-25 minutes until golden brown and bubbly.

Once baked, remove from the oven and let sit for 5 minutes before serving.